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Earth-Irritation is a world of ridiculousness that suffers near-constant apocalyptic events. In this world, the Legion of Nutty Heroes is based in Nutropolis.

At one point, the Exponential Man devoured the place, and only Lean-Apples Lad escaped to get help; thankfully, the E-Man's rampage was reversed, and Earth-Irritation was restored.

Other heroes of the world include Dvandumb Forz and the Relaxation Corps.

When the Deep Omnilooniverse formed, Earth-Irritation was sucked into its structure and became Looniverse-Ipos.